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Overdose can result in nausea, vomiting and diarrhea. The same has also been reported with the usual recommended dosages. Patients may experience neuromuscular hyperexcitability or convulsion if higher than recommended doses are given intravenously (particularly in the presence of renal failure).
No specific antidote is known. Treatment should be supportive and symptomatic according to the patient's clinical presentation. Excessive serum concentrations of either Piperacillin/Tazobactam may be reduced by hemodialysis.
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