Pharmahof Glizide Drug Interactions

Anabolic steroids may increase hypoglycemic effect; monitor blood glucose.
ACE inhibitors may increase hypoglycemic effect; monitor blood glucose.
CYP2C8/9 inhibitors may increase the levels/effects of glipizide. Example inhibitors include delavirdine, fluconazole, gemfibrozil, ketoconazole, nicardipine, NSAIDs, pioglitazone and sulfonamides.
H2 antagonists, antacids, oral sodium bicarbonate may increase the hypoglycemic effect; monitor glucose response.
Cyclosporine serum concentration is increased; monitor cyclosporine levels and renal function.
Beta-blockers decrease hypoglycemic effect, mask most hypoglycemic symptoms, decrease glycogenolysis; avoid use in diabetics with frequent hypoglycemic episodes.
Cholestyramine decreases glipizide's absorption; separate administration times.
CYP2C8/9 inducers may decrease the levels/effects of glipizide. Example inducers include carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine and secobarbital.
Ethanol (large amounts) decreases hypoglycemic effect; avoid concurrent use; rare disulfiram reaction.
Rifampin may decrease hypoglycemic effects of glipizide; monitor blood glucose.
Tacrolimus serum concentrations may be increased; monitor tacrolimus serum concentrations and renal function.
Corticosteroids cause hyperglycemia; adjustment of hypoglycemic agent may be necessary.