Omegacin Special Precautions

Careful Administration (Omegacin should be administered with care in the following patients): Patients with a history of hypersensitivity to carbapenem, penicillin or cephem antibiotics.
Patients with a personal or familial predisposition to allergic reactions such as bronchial asthma, rash or urticaria.
Patients with severe renal disorder [Central nervous system disorder such as convulsion or disturbed consciousness is likely to occur (see Pharmacology: Pharmacokinetics under Actions)].
Patients with poor oral food intake or who are receiving parenteral alimentation, and patients in poor general health [Patients should be observed carefully because vitamin K deficiency symptoms may develop].
Patients with a history of epilepsy or patients with central nervous system disorder [Central nervous system disorder such as convulsion or disturbed consciousness is likely to occur.]
Important Precautions: Since no methods are available to reliably predict the potential occurrence of shock or anaphylactoid reaction due to this product, the following measures should be taken: Patients should be carefully interviewed in advance to obtain any past history of such reactions to drugs. Any history of allergy to antibiotics or other agents must be ascertained.
Emergency measures must be available readily for the treatment of shock etc., when this product is used.
Patients should be resting and kept under careful observation from the beginning until after the end of administration of this product. Patients should be observed especially carefully immediately after the beginning of administration.
Effects on Laboratory Tests: False-positive results may occur in urine glucose tests with Benedict's solution, Fehling's solution and Clinitest, but not with Tes-Tape. Caution is required.
Positive results may occur in the direct Coombs' test. Caution is required.
Use in Children: The safety of this product in low birth weight infants, newborns, suckling infants, infants and children has not been established.
Use in the Elderly: Special attention should be paid to the following points when the product is used in elderly patients. The product should be used with care and the dose and dosing interval must be adjusted based on careful clinical observation of the patient's condition. (See Pharmacokinetics under Actions.)
Adverse reactions are likely to occur in elderly patients since they often have reduced physiological function.
In elderly patients, use of the product may be associated with the development of a bleeding tendency due to vitamin K deficiency.