Omegacin

Sepsis, pneumonia, lung abscess, secondary infections in chronic resp lesion, complicated cystitis, pyelonephritis, peritonitis, parametritis due to biapenem-susceptible strains of Staph sp, Strep sp, Strep pneumoniae, Enterococcus sp (excluding Enterococcus faecium), Moraxella sp, E. coli, Citrobacter sp, Klebsiella sp, Enterobacter sp, Serratia sp, Proteus sp, H. influenzae, Pseudomonas aeruginosa, Acinetobacter sp, Peptostreptococcus sp, Bacteroides sp, Prevotella sp & Fusobacterium sp.

IV drip infusion Adult 1.2 g daily (potency) in 2 divided doses over 30-60 min period. May be adjusted according to patient's age & symptoms. Max: 1.2 g daily (potency).

History of shock due to any of the excipients of Omegacin. Concomitant use w/ Na valproate.

History of hypersensitivity to carbapenem, penicillin or cephem antibiotics. Personal or familial predisposition to allergic reactions eg, bronchial asthma, rash or urticaria; convulsion or disturbed consciousness. Patients w/ poor oral food intake & general health or those receiving parenteral alimentation; CNS disorder or history of epilepsy. Carefully observe for development of vit K deficiency; immediately after beginning of administration. Obtain any history of anaphylactoid reactions to drugs or allergy to antibiotics or other agents. False +ve results in urine glucose test w/ Benedict's & Fehling's soln & Clinitest. +ve results in direct Coombs' test. Reduced potency when mixed w/ amino-acid prep containing L-cysteine or L-cystine. Severe renal disorder. Pregnancy. Discontinue breastfeeding during treatment. Low birth wt infants, newborns, suckling infants, infants & childn. Elderly (reduced physiological function & w/ development of bleeding tendency due to vit K deficiency).

Increased ALT (GPT); increased serum amylase. Rash, pruritus; eosinophilia, prolonged prothrombin time, basophilia, thrombocytosis, erythropenia, decreased hematocrit value & Hb, neutrophilia, lymphocytosis, monocytosis; increased AST (GOT), γ-glutamyl transferase, alkaline phosphatase, leucine aminopeptidase, LDH & bilirubin; increased N-acetyl-β-D-glucosaminidase, urinary β₂ microglobulin & BUN, proteinuria; diarrhea, nausea, abdominal pain; hyperkalemia, fever, headache. SJS/TEN.

Decreased valproate blood levels & recurrent epileptic seizures w/ Na valproate.

Other Beta-Lactams

J01DH05 - biapenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

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