For the treatment of postmenopausal symptoms, the minimum effective dose of 1.25 g gel per day (=0.75 mg of estradiol) should be recommended for 21 to 28 days per month. As the dose varies according to the needs, the average dose is 2.5 g of gel per day. Prevention of osteoporosis, the minimum effective dose is 2.5 g of estrogen gel once daily for most patients.