Nosze: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Per mL Latanoprost 50 mcg

Indications/Uses

Reduction of elevated IOP in patients w/ open-angle glaucoma, chronic angle closure glaucoma, & ocular HTN; paed patients w/ elevated IOP & paed glaucoma.

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Dosage/Direction for Use

Adult (including the elderly) & paed 1 drop in affected eye(s) once daily, optimally in the evening. Max: Once daily. Administer at least 5 min apart if >1 topical ophth drug is being used.

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Overdosage

View Nosze overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity.

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Special Precautions

Avoid in patients w/ active herpes simplex keratitis & w/ history of recurrent herpetic keratitis specifically associated w/ prostaglandin analogues. Increased brown pigmentation of iris especially those w/ mixed colored irides containing the color brown at baseline. Reversible eyelid pigmentation & eyelash changes. Macular edema including cystoid macular edema in aphakic & pseudophakic patients w/ torn posterior lens cap, or patients w/ known risk factors for macular edema. Inflammatory neovascular glaucoma. Patients w/ history of herpetic keratitis. Remove contact lenses before eye drops instillation & may reinsert after 15 min. Regularly examine patients who develop increased iris pigmentation. May affect ability to drive & use machines. Pregnancy & lactation. Childn <1 yr. Pre-term infants (<36 wk gestational age).

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Use In Pregnancy & Lactation

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Adverse Reactions

Herpetic keratitis; dizziness, headache; eye irritation (burning, grittiness, itching, stinging & foreign body sensation), & pain, eyelash & vellus hair changes of eyelid (increased length, thickness, pigmentation & number of eyelashes), ocular hyperaemia, iris hyperpigmentation, blepharitis, conjunctivitis, macular oedema including cystoid macular oedema, photophobia, eyelid oedema, keratitis, uveitis, corneal oedema, iritis, punctate keratitis, corneal erosion, trichiasis, blurred vision, periorbital & lid changes resulting in deepening of eyelid sulcus, darkening of palpebral skin of eyelids, localized skin reaction on eyelids, iris cyst, pseudopemphigoid of ocular conjunctiva; angina, palpitations, unstable angina; asthma, dyspnoea, asthma aggravation, acute asthma attacks; rash, pruritus; myalgia, arthralgia; chest pain.

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Drug Interactions

Not recommended in concomitant use of ≥2 prostaglandins, prostaglandin analogs or derivatives.

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Storage

View Nosze storage conditions for details to ensure optimal shelf-life.

Description

View Nosze description for details of the chemical structure and excipients (inactive components).

Action

View Nosze mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antiglaucoma Preparations

ATC Classification

S01EE01 - latanoprost ; Belongs to the class of prostaglandin analogues. Used in the treatment of glaucoma.

Thai FDA Category

Presentation/Packing

Form

Nosze ophth soln 0.005%

Packing/Price

2.5 mL x 1's

Nosze

latanoprost

Manufacturer:

Siam Bheasach

Distributor:

Siam Pharmaceutical

Marketer:

Siam Pharmaceutical