Pregnancy: NSAIDs should be avoiding during pregnancy or avoiding them unless the potential benefit outweighs the risk. NSAIDs should be avoided during the third trimester because use is associated with a risk of closure of fetal ductus arteriosus in utero and possibly persistent pulmonary hypertension of the newborn. In addition, the onset of labour may be delayed and its duration may be increased.
No clinical data are available on the use of etoricoxib in pregnant woman. In animal studies, reproductive toxicity was shown. Therefore NOSMEN is contraindicated in pregnancy. If a women becomes pregnant during treatment, NOSMEN must be discontinued.
Lactation: It is unknown whether etoricoxib is excreted into human breast milk. However, etoricoxib is excreted into the milk of lactating rats. Women who use etoricoxib must not breast feed.
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