NIKP-Manidipine Dosage/Direction for Use

The usual adult dosage and administration for each preparation are as follows.
NIKP-Manidipine tablet 10 mg: 1-2 tablets orally once a day with food in morning or 30 minutes after breakfast.
NIKP-Manidipine tablet 20 mg: ½-1 tablet orally once a day with food in morning or 30 minutes after breakfast.
Remark: Administration should be started at a dose of 5 mg daily and titrated up as needed.
Elderly: Since it is generally acknowledged that excessive reduction in blood pressure should be avoided in elderly patients. (Cerebral infarction may occur.). Thus when NIKP-Manidipine tablet is given in elderly, it is advisable to start with a low dose, treat with attention and under close observation.
Children: The safety of NIKP-Manidipine tablets in children has not been established. (No clinical experience.) Thus, it should not be administered in children.
Mode of Administration: Since concomitant food intake enhances significantly (about 50%) the extent of absorption, but impacts slightly the rate of absorption. Therefore, Manidipine is suggested to be taken with food in morning or 30 minutes after breakfast.
NIKP-Manidipine tablet 10 mg and NIKP-Manidipine tablet 20 mg can be divided. Due to it is not controlled release dosage form.