NIKP-Manidipine: Dosing, Side Effect & Interaction

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Manidipine HCl

Indications/Uses

Mild, moderate & severe HTN. HTN w/ renal impairment.

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Dosage/Direction for Use

Initially 5 mg once daily & titrated up as needed. Adult 10-20 mg once daily.

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Overdosage

View NIKP-Manidipine overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Pregnancy.

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Special Precautions

Avoid abrupt w/drawal. W/draw drug or reduce dose if transient loss of consciousness or cerebral infarction is observed. May cause excessive decrease in BP. Dialysis effluent in patients on continuous ambulatory peritoneal dialysis may become cloudy w/ increased lipid (eg, triglyceride) levels; distinguish from peritonitis. May affect operating hazardous machinery eg, working in heights or driving car. Serious hepatic disorder. Not to be administered to pregnant women or women suspected of being pregnant. Avoid during lactation; discontinue breastfeeding if treatment is necessary. Childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Excessive decrease in BP; agranulocytosis & thrombocytopenia; ventricular & supraventricular extrasystole; erythroderma.

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Drug Interactions

Enhanced effects w/ other antihypertensives. Increased blood digoxin conc. Enhanced effects w/ cimetidine. Reduced effects w/ rifampicin. Elevated blood conc w/ grapefruit juice.

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Storage

View NIKP-Manidipine storage conditions for details to ensure optimal shelf-life.

Description

View NIKP-Manidipine description for details of the chemical structure and excipients (inactive components).

Action

View NIKP-Manidipine mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists

ATC Classification

C08CA11 - manidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Thai FDA Category

Presentation/Packing

Form

NIKP-Manidipine tab 10 mg

Packing/Price

10 × 10's

Form

NIKP-Manidipine tab 20 mg

Packing/Price

10 × 10's

NIKP-Manidipine

manidipine

Manufacturer:

Nichi-Iko

Distributor:

DKSH

Marketer:

Nichi-Iko