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Caution should be exercised in patients with hypotension as there is a risk of further reduction in blood pressure.
In patients with impaired liver function careful monitoring and, in severe cases, a dose reduction may be necessary.
Caution in patients whose cardiac reserve is poor. Deterioration of heart failure has occasionally been observed with nifedipine.
Diabetic patients taking nifedipine may require adjustment of their control.
In dialysis patients with malignant hypertension and hypovolaemia, a marked decrease in blood pressure can occur.
Effects on ability to drive and operate machine: Reactions to the drug, which vary in intensity from individual to individual, may impair the ability to drive or to operate machinery. This applies particularly at the start of treatment, on changing the medication and in combination with alcohol.
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