The safety of Filgrastim has not been established in pregnant women, though there is no evidence of teratogenic effects of NEUTROMAX from studies in rats and rabbits. An increased incidence of embryo-loss has been observed in rabbits, but no malformation has been observed. In pregnancy, the possible risk of NEUTROMAX use to the fetus must be weighed against the expected therapeutic benefit. It is not known whether NEUTROMAX is excreted in human milk; consequently, it is not recommended for use in nursing women.