Neutromax: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing Local Product Insert

Concise Prescribing Info

Contents

Filgrastim (recombinant methionyl, human granulocyte colony stimulating factor)

Indications/Uses

Reduction in the duration of neutropenia & the incidence of febrile neutropenia in patients on chemotherapy. Patients receiving myeloablative chemotherapy followed by bone marrow transplantation. Mobilization of hematopoietic progenitor cells into the peripheral blood. Chronic administration for reducing the incidence & duration of neutropenia in patients w/ congenital, cyclic & idiopathic neutropenia. Reduction in the time required for neutrophil recovery & the duration of fever after induction or consolidation chemotherapy treatment of adults w/ acute myelogenous leukemia.

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Dosage/Direction for Use

Chemotherapy-induced neutropenia 5 mcg/kg daily SC or IV. Myeloablative chemotherapy followed by bone marrow transplantation 10 mcg/kg daily given 30 min or 24 hr IV infusion or continuous 24 hr SC infusion. Peripheral blood progenitor cell mobilization 10 mcg/kg SC once daily for 6-7 days w/ leukapheresis performed on day 5, 6, & 7. Severe chronic neutropenia 12 mcg/kg daily SC (single or divided dose). Idiopathic or cyclic neutropenia 5 mcg/kg daily SC (single or divided dose). Acute myelogenous leukemia 5 mcg/kg daily. Should be started at least 24 hr after chemotherapy & discontinued at least 24 hr before the next dose of chemotherapy.

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Overdosage

View Neutromax overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity. Not to be used to increase the dose of cytotoxic chemotherapy beyond established dosage regimens & should not be administered in patients w/ severe congenital neutropenia (Kostmann's syndrome) w/ abnormal cytogenetics.

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Special Precautions

Malignancy w/ myeloid characteristics, pre-malignant myeloid condition. Monitor for WBC, platelet & hematocrit counts. Patients w/ high-dose chemotherapy. Monitor bone density in patients w/ osteoporotic bone disease w/ continuous therapy for >6 mth. Severe renal or hepatic impairment. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Musculoskeletal pain (controllable w/ analgesics), urinary abnormalities, decreased BP & raised liver enzyme. Nausea & vomiting, alopecia, diarrhea, fatigue, anorexia, mucositis, headache, cough, skin rash, chest pain, generalized weakness, sore throat, constipation & unspecified pain.

Drug Interactions

Chemotherapy (not recommended in the period from 24 hr before to 24 hr after).

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Neutromax detailed prescribing information

Storage

View Neutromax storage conditions for details to ensure optimal shelf-life.

Description

View Neutromax description for details of the chemical structure and excipients (inactive components).

Action

View Neutromax mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Supportive Care Therapy / Haematopoietic Agents

ATC Classification

L03AA02 - filgrastim ; Belongs to the class of colony stimulating factors. Used as immunostimulants.

Thai FDA Category

Presentation/Packing

Form

Neutromax inj 300 mcg/mL

Packing/Price

1's

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Form

Neutromax inj 480 mcg/1.6 mL

Packing/Price

1's

Neutromax

filgrastim

Manufacturer:

Bio Sidus

Distributor:

Cosma Medical