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Congenital abnormalities have been reported in association with NSAID administration in man; however, these are low in frequency and do not appear to follow any discernible pattern. In view of the known effects of NSAIDs on the foetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy is contraindicated. NSAIDs should not be used during the first two trimester of the pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.
Naproxen can appear in the breast milk of lactating women. Naproxen should be avoided when breastfeeding.
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