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Montelukast has been administered to adults with asthma in dosages up to 200 mg daily for 22 weeks, and in dosages up to 900 mg daily for approximately 1 week without clinically important adverse experiences. There have been reports of acute overdosage with Montelukast doses of up to 1 g in adults and children. The most frequently reported adverse experiences that were reported included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity.
If acute overdosage of Montelukast occurs, supportive and symptomatic treatment should be initiated and the patient closely observed. If indicated, unabsorbed material should be removed from the GI tract. Whether peritoneal dialysis or hemodialysis removes Montelukast is unknown.
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