Muloz

Prophylaxis & chronic treatment of asthma including prevention of day- & nighttime symptoms, aspirin-sensitive asthmatic patients & prevention of exercise-induced bronchoconstriction in adult & ped patients ≥6 mth. Relief of day- & nighttime symptoms of allergic rhinitis: seasonal allergic rhinitis in adult & ped patients ≥2 yr, & perennial allergic rhinitis in adult & ped patients ≥6 mth.

Take 1 dose in the evening. Asthma &/or allergic rhinitis Adult & adolescent ≥15 yr 10 mg once daily. Childn 6-14 yr 5 mg once daily. Moderate to severe asthma Take once daily concomitantly w/ inhaled corticosteroids to provide additional benefit. Prevention of exercise-induced bronchoconstriction Administer at least 2 hr before exercise.

May be taken with or without food.

Hypersensitivity.

Not to be abruptly substituted for oral or inhaled corticosteroids. Not indicated in relief of bronchospasm in acute asthma attacks including status asthmaticus. Neuropsychiatric events. Systemic eosinophilia sometimes presenting w/ clinical features of vasculitis consistent w/ Churg-Strauss syndrome. Reassess patients who develop eosinophilia, vasculitis rash, worsening pulmonary symptoms, cardiac complications &/or neuropathy. Pregnancy & lactation.

Upper resp infection; increased bleeding tendency, thrombocytopenia; hypersensitivity reactions including anaphylaxis, hepatic eosinophilic infiltration; hyperkinesia, agitation including aggressive behavior or hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, dysphemia (stuttering), hallucinations, insomnia, memory impairment, obsessive-compulsive symptoms, psychomotor hyperactivity (including irritability, restlessness & tremor), somnambulism, suicidal thinking & behavior, tic; headache, dizziness, drowsiness, paresthesia/hypoesthesia, seizure; palpitations; asthma, epistaxis, eosinophilic granulomatosis w/ polyangiitis (Churg-Strauss syndrome), pulmonary eosinophilia; abdominal pain, diarrhea, dyspepsia, nausea, vomiting, dry mouth; increased ALT & AST, hepatitis including cholestatic, hepatocellular, mixed-pattern liver injury; eczematous dermatitis, angioedema, bruising, erythema multiforme & nodosum, pruritus, rash, urticaria; arthralgia, myalgia including muscle cramps; enuresis in childn; thirst, asthenia/fatigue, edema, pyrexia.

Decreased AUC w/ phenobarb.

Antiasthmatic & COPD Preparations / Antihistamines & Antiallergics

R03DC03 - montelukast ; Belongs to the class of leukotriene receptor antagonists. Used in the systemic treatment of obstructive airway diseases.

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