Moxicap 500 Dosage/Direction for Use

Adults and children ≥ 40 kg: Standard dose: 500 mg every 12 hours or 250 mg every 8 hours in mild to moderate infection, increased if necessary up to 875 mg every 12 hours or 500 mg every 8 hours in severe infection.
Lower respiratory tract infection: 875 mg every 12 hours or 500 mg orally every 8 hours.
Community-acquired pneumonia: 1 g orally 3 times daily for a maximum of 5 days; use in combination with a macrolide or doxycycline.
Simple acute urinary tract infection: Two 3 g doses with 10-12 hours between the doses.
Gonorrhea: Single 3 g dose.
Helicobacter pylori gastrointestinal tract infection: 1 g twice daily, in combination with a proton pump inhibitor (PPI) and clarithromycin or metronidazole (triple therapy) or a PPI, clarithromycin, and metronidazole (quadruple therapy) for 14 days: use of triple therapy should be reserved for areas where clarithromycin resistance is low (<15%) or eradication rates are high (>85%).
Prophylaxis of bacterial endocarditis: 2 g 30 to 60 minutes before procedure.
Children < 40 kg: Standard dose: 125 mg every 8 hours in mild to moderate infection, increased if necessary up to 250 mg every 8 hours in severe infection.
Prophylaxis of bacterial endocarditis: 50 mg/kg 30 to 60 minutes before procedure.
Renal impairment: GFR ≥ 30 mL/min: No dosage adjustment necessary.
GFR 10 to 30 mL/min: 250 to 500 mg every 12 hours.
GFR less than 10 mL/min: 250 to 500 mg every 24 hours.
Hemodialysis: 250 to 500 mg every 24 hours after dialysis.
Hepatic impairment: No specific recommendations are available.