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Pharmacology: Pharmacodynamics: Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Pharmacokinetics: Absorption: Tmax, Oral: 1 to 2 hours.
Effects of food: No effect when administered at the start of a light meal.
Distribution: Protein binding: 20%.
Excretion: Renal: approximately 60% (mostly unchanged).
Elimination Half Life: 61.3 minutes.
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