Sign Out
In case of acute or chronic overdose, the observed side effects may be increased, including renal, hepatic, and cardiac toxicities (see Adverse reactions).
If bone marrow aplasia occurs as a result of acute overdose with mitoxantrone, it may continue for up to 3 weeks.
The extent of bone marrow depression and thrombocytopenia will determine the course of treatment in acute and chronic overdose.
To counteract agranulocytosis and thrombocytopenia, granulocyte colony-stimulating factor and thrombocyte concentrates may be necessary.
There is no specific antidote for mitoxantrone overdose. Emergency procedures should include appropriate corrective and supportive measures.
Mitoxantrone is rapidly eliminated from the blood plasma and shows high tissue affinity; therefore it cannot be eliminated by dialysis.
Infection prophylaxis with antibiotics should be considered.
Every overdose requires careful monitoring to identify as early as possible, any delayed complications.
Continue with Google