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Mosapride should be administered with caution when co-administered with anticholinergic agents (atropine sulfate and butyl-scopolamine bromide, etc.) As gastroprokinetic effect of Mosapride is exerted by activation of the cholinergic nerves, concomitant use of anticholinergic agents may decrease the effect Mosapride. Therefore, in the case of the concomitant use of anticholinergic agents, precautions such as taking the drugs at intervals should be taken.
When erythromycin at 1,200 mg/day was concomitantly administered with this drug at 15 mg/day, in comparison with a single administration of Mosapride, maximum blood concentration of Mosapride increased from 42.1 ng/mL to 65.7 ng/mL, the half-life was prolonged from 1.6 hours to 2.4 hours and AUC0-4 increased from 62 ng·hr/mL to 114 ng·hr/mL (Healthy adult).
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