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Initial dose: 2.5 mg two to three times a day. Depending on results of supine and standing blood pressure recordings, this dosage can be increased weekly up to a dose of 10 mg three times a day. Higher dosages have not been studied.
It is essential to individually adjust the dosage to achieve a correct balance between the therapeutic effects and the possible risks.
No data is available regarding the use in children, elderly and in patients with impaired hepatic or renal function (see Contraindications).
The last daily dose should be taken at least 4 hours before bedtime in order to prevent supine hypertension (see also Precautions).
Midodrine may be taken with food (see Pharmacology: Pharmacokinetics under Actions).
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