Midorine Tablets P.L.: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Midodrine HCl

Indications/Uses

Symptomatic orthostatic hypotension due to autonomic dysfunction when corrective factors have been ruled out & other forms of treatment are inadequate.

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Dosage/Direction for Use

Initially 2.5 mg bid-tid, may be increased wkly up to 10 mg tid.

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Overdosage

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Administration

Should be taken with food: The last daily dose should be taken at least 4 hr before bedtime to prevent supine HTN.

Contraindications

Hypersensitivity. HTN, bradycardia, urinary retention, ischaemic heart disease, CHF, cardiac conduction disturbances, narrow angle glaucoma, serious obliterative blood vessel disease, cerebrovascular occlusions & vessel spasms, aortic aneurism, proliferative diabetic retinopathy, thyrotoxicosis, pheochromocytoma, severe renal insufficiency (CrCl <30 mL/min) & serious prostate disorder.

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Special Precautions

Renal & hepatic impairment. Patients w/ initial supine systolic pressure >180 mmHg, urinary retention problems, orthostatic hypotensive diabetics, & those w/ visual problems who are also taking fludrocortisone. Monitor supine & sitting BP in maintenance therapy. Evaluate potential supine & sitting HTN at initiation of treatment. Concomitant use w/ cardiac glycosides (eg, digitalis), psychopharmacologic agents, β-blockers or other agents that directly or indirectly reduce heart rate, fludrocortisone acetate. Discontinue & re-evaluate if bradycardia occurs. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Chills & pilo-erection; paresthesia & pruritus, supine HTN. Urinary retention, headache.

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Drug Interactions

Increased BP w/ reserpine, guanethidine, TCAs, antihistamines, thyroid hormones & MAOIs. Effect may be blocked by α-adrenergic blockers eg, prazosine & doxazosine. Heart block may occur w/ digitalis. May potentiate hypertensive effects of fludrocortisone acetate. Drugs that directly or indirectly reduce heart rate.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Midorine Tablets P.L. detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Vasoconstrictors

ATC Classification

C01CA17 - midodrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.

Thai FDA Category

Presentation/Packing

Form

Midorine Tablets P.L. tab 2.5 mg

Packing/Price

10 × 10's

Midorine Tablets P.L.

midodrine

Manufacturer:

Pei Li Pharmaceutical

Distributor:

Cosma Medical

Marketer:

Cosma Medical