Avoid concomitant use of ethinyl estradiol and levonorgestrel with any of the following: anastrozole, griseofulvin, pimozide, pirfenidone.
Ethinyl estradiol and levonorgestrel may increase the level of aripiprazole, benzodiazepines (metabolized by oxidation), corticosteroids, CYP1A2 substrates such as lomitapide, pimozide, pirfenidone, ropinirole, selegiline, theophylline derivatives such as tipranavir, tizanidine, tranexamic acid, voriconazole.
The level of ethinyl estradiol and levonorgestrel may be increased by ascorbic acid, boceprevir, cobicistat, mifepristone, NSAID, voriconazole.
Ethinyl estradiol and levonorgestrel may decrease the level of anastrozole, chenodiol, hyaluronidase, lamotrigine, thyroid product, ursodiol, vitamin K antagonists.
The level of ethinyl estradiol and levonorgestrel may be decreased by acitretin, aminoglutethimide, aprepitant, armodafinil, artemether, barbiturate, bexarotene, bile acid sequestrants, boceprevir, bosentan, carbamazepine, clobazam, cobicistat, colesevelam, deferasirox, elvitegravir, exenatide, felbamate, fosaprepitant, fosphenytoin, griseofulvin, lamotrigine, mifepristone, modafinil, mycophenolate, nafcillin, nevirapine, oxcarbazepine, perampanel, phenytoin, protease inhibitors, prucalopride, retinoic acid derivatives, rifamycin derivatives, rufinamide, St. John's wort, telaprevir, tipranavir, tocilizumab, topiramate.
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