CNS: Dizziness, headache, mental depression, migraine.
Dermatologic: Melasma, rash.
Endocrine: Breast pain, tenderness, enlargement, secretion diminution in lactation when given immediately postpartum.
GI: Abdominal cramp, bloating, cholestatic jaundice, nausea and vomiting.
GU: Amenorrhea during and after treatment, breakthrough bleeding, spotting, change in menstrual flow, change in cervical erosion and secretions, invasive cervical cancer, temporary infertility after discontinuation, vaginal candidiasis.
Ophthalmic: Changes in corneal curvature, contact lens intolerance, neuro-ocular lesions.
Miscellaneous: Edema, reduced carbohydrate tolerance, weight change, prevalence of cervical Chlamydia trachomatis may be increased, hirsutism.
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