The vaccine is indicated for active immunization against infection caused by HAV in persons over age of 18 months. It can be used for primary immunization. Hepatitis A vaccine is recommended for pre-exposure prophylaxis of individuals at increased risk of infection and post-exposure prophylaxis. Thus, the vaccine is indicated in the following conditions: Residents of communities with high endemic rates or recurrent outbreaks of Hepatitis A; Travellers to countries where Hepatitis A is endemic, especially when the travel involves rural or primitive conditions; Members of the armed forces, emergency relief workers and others likely to be posted abroad at short notice to areas with high rates of HAV infection; Residents and staff of institutions where there is an ongoing problem with HAV transmission; Inmates of correctional facilities in which there is an ongoing problem with HAV infection; People with life style determined risks of infection, including those engaging in oral or intravenous illicit drug use in unsanitary conditions; People with chronic liver disease who may be at increased risk of fulminant hepatitis A; Zoo-keepers, veterinarians and researchers who handle non-human primates.