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Metoprolol should be used during pregnancy (in particular during the first three months) only after very accurate diagnosis and after evaluation of the benefits and possible risks, as insufficient experience has been gathered to date about such application, particularly in the first weeks of pregnancy. Due to the possibility of the occurrence of bradycardia, hypotension and hypoglycaemia in the newborn, the therapy should be discontinued 48 - 72 hours before the expected date of birth. If this is not possible, the newborn must be carefully monitored for 48 to 72 hours after delivery.
Metoprolol passes over to the breast milk. Although the amount of the active substance ingested with the milk probably represents no risk to the child, infants should be monitored for symptoms of a beta blockade.
