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Overdosage of Colistimethate sodium can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorder of speech, apnea, respiratory muscle paralysis, respiratory arrest, and death. Overdosage of the drug may also cause acute renal failure, manifested as decreased urine output and increase in serum concentrations of BUN and creatinine.
Treatment for overdosage: The drug should be discontinued and initiate supportive treatment.
Colistimethate sodium may be removed by hemodialysis and, to a lesser extent, by peritoneal dialysis.
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