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1. Since nephrotoxic effects may be additive, concurrent or sequential use of Colistimethate sodium and other drugs with similar toxic potentials (e.g., aminoglycosides, amphotericin B, capreomycin, cephalothin, methoxyflurane, polymyxin B sulfate, vancomycin) should be avoided, if possible.
2. Neuromuscular blocking agents (e.g., tubocurarine, succinylcholine, ether, decamethonium, gallamine) and other drugs (e.g., sodium citrate) potentiate neuromuscular blockade. These drugs should be used with extreme caution in patients receiving Colistimethate sodium.
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