Lybalin Dosage/Direction for Use

The dose range is 150 to 600 mg per day given in either two or three divided doses. Pregabalin may be taken with or without food.
Neuropathic Pain: Pregabalin treatment can be started at a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day within 1 week, and if needed, to a maximum dose of 600 mg daily after an additional 7 days interval. Although a maximum daily dose of 300 mg is recommended in diabetic peripheral neuropathy.
Epilepsy: Pregabalin treatment can be started at a dose of 150 mg per day, 75 mg twice daily or 50 mg 3 times daily. Based on the individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. The maximum dosage of 600 mg per day may be achieved after an additional week.
Generalized Anxiety Disorder: Pregabalin treatment can be started at a dose of 150 mg per day in 2 to 3 divided doses. Based on the individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. Following an additional week the dosage may be increased to 450 mg per day. The maximum dosage of 600 mg per day may be achieved after an additional week.
Fibromyalgia: Pregabalin treatment can be started at a dose of 150 mg per day (75 mg two times a day) and may be increased to 300 mg per day (150 mg two times a day) within 1 week based on efficacy and tolerability. Patients who do not experience adequate benefit with 300 mg per day may have dosage further increased to the maximum recommended dosage of 450 mg daily (225 mg twice daily).
Dosage in Renal Function Impairment: The dose of pregabalin for patients with renal impairment should be reduced according to creatinine clearance (CrCl): CrCl 30 to less than 60 mL/minute: Starting daily dose: 75 mg; maximum daily dose: 300 mg; daily dose given in 2 or 3 divided doses.
CrCl 15 to less than 30 mL/minute: Starting daily dose: 25 to 50 mg; maximum daily dose: 150 mg; daily dose given in 2 divided doses or once daily.
CrCl less than 15 mL/minute: Starting daily dose: 25 mg; maximum daily dose: 75 mg; daily dose given as one dose.
For patients undergoing hemodialysis, the pregabalin daily dose should be adjusted based on renal function. In addition to the daily dose adjustment, a supplemental dose should be given immediately following every 4-hour hemodialysis treatment. Individuals receiving the 25-mg once daily dosage regimen should receive a supplemental dose of 25 or 50 mg, those receiving the 25- to 50-mg once daily dosage regimen should receive a supplemental dose of 50 or 75 mg, those receiving the 50- to 75-mg once daily dosage regimen should receive a supplemental dose of 75 or 100 mg, and those receiving the 75-mg once daily dosage regimen should receive a supplemental dose of 100 or 150 mg.