Lupifil-P | Overdosage | MIMS Thailand

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Full Prescribing Info

Overdosage

The maximum amount of pegfilgrastim that can be safely administered in single or multiple doses has not been determined. Single subcutaneous dose of 300 mcg/kg has been administered to limited number of heathy volunteers and patients with non-small cell lung cancer without serious adverse effects. These patients experienced a mean maximum absolute neutrophil count (ANC) of 55 x 10⁹/L, with a corresponding mean maximum WBC of 67 x 10⁹/L. The absolute maximum ANC observed was 96 x 10⁹/L with a corresponding absolute maximum WBC observed of 120 x 10⁹/L. The duration of leukocytosis ranged from 6 to 13 days. The effectiveness of leukapheresis in the management of symptomatic individuals with pegfilgrastim-induced leukocytosis has not been studied.

Lupifil-P Overdosage

pegfilgrastim

Manufacturer:

Lupin Limited

Distributor:

Atlanta Medicare

Marketer:

Atlanta Medicare