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Lupifil-P (pegfilgrastim) is supplied in pre-filled syringes in the form of clear, colorless, preservative-free solution for subcutaneous use.
Each PFS of 0.6 mL contains Recombinant Pegylated Granulocyte Colony Stimulating Factor, r-DNA origin 6.0 mg, Acetate 0.35 mg, Sodium 0.021 mg, Sorbitol 30.0mg, Polysorbate 20 0.02 mg, Water for Injection q.s. to 0.6 ml.
Pegfilgastrim is a covalent conjugate of recombinant methionyl human G-CSF (filgrastim) and monomethoxypolyethylene glycol. It belongs to Hematopoietic growth factor therapeutic class. Filgrastim is a water-soluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (KD). To produce pegfilgrastim, a 20 kD monomethoxypolyethylene glycol molecule is covalently bound to the N-terminal methionyl residue of filgrastim. The average molecular weight of pegfilgrastim is approximately 39 kD. Pegfilgrastim has reduced renal clearance and prolonged persistence in vivo as compared to filgrastim, which makes it behave like a sustained duration filgrastim.
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