Losu Drug Interactions

Cytochrome P450 Effect: Substrate of CYP2C9 (major).
Increased Effect/Toxicity: CYP2C9 inhibitors may increase the levels/effects of glimepi­ride; example inhibitors include delavirdine, ketoconazole, nicardipine, NSAIDs, and piog­litazone.
Beta-blockers, chloramphenicol, cimetidine, clofibrate, fluconazole, gemfibrozil, pegvisomant, salicylates, sulfonamides, and tricyclic antidepressants may increase the hypoglycemic effects of glimepiride. Glimepiride may increase effects of coumarins and cyclosporine. Sulfonylureas may induce a disulfiram-like reaction.
Decreased Effect: CYP2C9 inducers may  decrease  the levels/effects of  glimepiride; example inducers include carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, and secobarbital. There may be a decreased effect of glimepiride with corticosteroids, estrogens, oral contraceptives, thiazide and other diuretics, phenothiazines, NSAIDs, thyroid products, nicotinic acid, isoniazid, sympathomimetics, urinary alkalinizers, and charcoal.
Note: However, pooled data did not demonstrate drug interactions with calcium channel blockers, estrogens, NSAIDs, HMG-CoA reductase inhibitors, sulfonamides, or thyroid hormone.
Ethanol/Nutrition/Herb Interactions: Ethanol: Caution with ethanol (may cause hypoglycemia).
Herb/Nutraceutical: Caution with chromium, garlic, gymnema (may cause hypoglycemia).