Locoa Contraindications

Patients with peptic ulcer (see Precautions) [Gastric mucosal barrier decreased by inhibition of prostaglandin synthesis may aggravate peptic ulcer].
Patients with severe blood abnormality [Blood disorder may develop, aggravating blood abnormality].
Patients with severe liver disorder [Abnormal hepatic function may develop, aggravating liver disorder].
Patients with severe renal disorder [Renal blood flow decreased by inhibition of prostaglandin synthesis, among others, may aggravate renal disorder].
Patients with severe cardiac dysfunction [Water and sodium retention induced by inhibition of prostaglandin synthesis may aggravate cardiac dysfunction].
Patients with severe hypertension [Water and sodium retention induced by inhibition of prostaglandin synthesis may further increase blood pressure].
Patients with a history of hypersensitivity to the components of LOCOA or flurbiprofen.
Patients with current or previous aspirin-induced asthma (asthmatic attacks induced by nonsteroidal anti-inflammatory analgesics and other relevant drugs) (See Adverse Reactions) [Asthmatic attacks may be induced].
Patients on enoxacin hydrate, lomefloxacin, norfloxacin, or prulifloxacin (see Interactions).
Use in Pregnancy: Women in the third trimester of pregnancy (see Use in Pregnancy & Lactation).