Kosamine Drug Interactions

Glucosamine administered orally can enhance the adsorption of concomitantly administered tetracycline.
Glucosamine administered orally can decrease the adsorption of concomitantly administered penicillin or chloramphenicol.
Glucosamine coadministered with antidiabetic agents, such as acarbose, acetohexamide, chlorpropamide, glimepiride, glipizide, glyburide, metformin, miglitol, pioglitazone, repaglinide, rosiglitazone, tolazamide, tolbutamide, troglitazone, may reduce antidiabetic agents effectiveness. Closed monitoring of blood glucose levels with coadministration is advised.
Glucosamine may reduce effectiveness of coadministered doxorubicin; avoid coadministration.
Glucosamine may reduce effectiveness of coadministered etoposide; avoid coadministration.
Glucosamine may reduce effectiveness of coadministered teniposide; avoid coadministration.
Glucosamine may elevate serum International Normalized Ratio (INR) values and potentiates anticoagulant effects of coadministered warfarin, therefore increases risk of bleeding. During concomitant treatment, Warfarin dosage adjustments may be required, and closely monitoring of the INR is needed.
Glucosamine can be coadministered with steroidal agents or non-steroidal anti-inflammatory drugs (NSAIDs) for synergy.