Kabiven/Kabiven Peripheral Overdosage

Nausea, vomiting and sweating have been observed during infusion of amino acids at rates exceeding the recommended maximum rate.
An impaired capacity to eliminate fat may lead to the fat overload syndrome as a result of overdosage, but also at recommended rates of infusion in association with a sudden change in the patient's clinical condition eg, renal function impairment or infection.
The fat overload syndrome is characterized by hyperlipemia, fever, fat infiltration, hepatomegaly, splenomegaly, anaemia, leucopenia, thrombocytopenia, blood coagulation disorders and coma. These changes are invariably reversible on discontinuation of the fat infusion.
If symptoms of overdose occur, the infusion should be slowed down or discontinued.
Additionally, overdose might cause fluid overload, electrolyte imbalances, hyperglycemia and hyperosmolarity.
In some rare serious cases, haemodialysis, hemofiltration or hemodia-filtration may be necessary.