Kabiven/Kabiven Peripheral Adverse Reactions

Kabiven/Kabiven Peripheral may cause a rise in body temperature (incidence <3%) and, less frequently, shivering, chills and nausea/vomiting (incidence <1%). Transient increases in liver enzymes during IV nutrition have also been reported.
As with all hypertonic solutions for infusion, thrombophlebitis may occur if peripheral veins are used.
Reports of other undesirable effects in conjunction with Kabiven/Kabiven Peripheral infusions are extremely rare: less than one adverse event per million infusions. Hypersensitivity reactions (anaphylactic reaction, skin rash, urticaria), respiratory symptoms (eg, tachypnea) and hyper/hypotension have been described.
Hemolysis, reticulocytosis, abdominal pain, headache, (nausea, vomiting - for Kabiven Peripheral only), tiredness and priapism have been reported.
Fat Overload Syndrome: An impaired capacity to eliminate Intralipid (the fat component in Kabiven/Kabiven Peripheral) may lead to the fat overload syndrome as a result of overdosage, but also at recommended rates of infusion in association with a sudden change in the patient's clinical condition, eg, renal function impairment or infection for Kabiven, or resulting in severe renal or hepatic impairment for Kabiven Peripheral.
The fat overload syndrome is characterized by hyperlipemia, fever, fat infiltration (for Kabiven only), hepatomegaly, splenomegaly, anaemia, leucopenia, thrombocytopenia, blood coagulation disorders and coma. All symptoms are usually reversible if the infusion is discontinued.