Japrolox Contraindications

JAPROLOX TABLETS is contraindicated in the following patients: Patients with peptic ulcers [peptic ulcers may be aggravated due to reduced gastric blood flow resulting from inhibition of prostaglandin biosynthesis]. (See "Careful administration" under Precautions.)
Patients with severe blood disorders. [Platelet dysfunction may occur and the abnormality may be worsened.]
Patients with severe hepatic function disorders. [Liver damage has been reported as an adverse reaction, and the patient's liver dysfunction may be aggravated.]
Patients with severe renal impairment. [Adverse reactions such as acute kidney injury, nephritic syndrome, etc. may occur.]
Patients with severe cardiac function failure. [Cardiac symptoms may be exacerbated because inhibition of prostaglandin biosynthesis in the kidneys may cause edema and an increase in circulating body fluid volume, with a consequent increase in cardiac work.]
Patients with a history of hypersensitivity to any ingredients of JAPROLOX.
Patients with a history of aspirin-induced asthma (induction of asthmatic attack with non-steroidal anti-inflammatory-analgesics, etc). [May induce an aspirin-induced asthmatic attack.]
Women in the late stages of pregnancy [see Use in Pregnancy & Lactation].