Holoxan Special Precautions

Before starting treatment, it is necessary to exclude or correct any obstruction of the efferent urinary tract, cystitis, infections and electrolyte imbalances. In general, Holoxan, like other cytostatics, should be used with care in weakened or elderly patients and in patients who have had previous radiotherapy. Patients with a weakened immune system eg, those with diabetes mellitus, chronic hepatic and renal impairments, also require special care. Patients with brain metastases, cerebral symptoms and/or deteriorated renal function must be kept under close observation.
Contraceptive Measures: Ifosfamide can cause congenital anomalies. Conception during treatment is not advisable. Men to be treated with Holoxan should be informed about sperm preservation before treatment. Women should not become pregnant during treatment. Should they still conceive during treatment, they should seek genetic consultation. The duration of contraception after the end of chemotherapy depends on the prognosis of the primary disease and on the intensity of the patient's desire for a child. The possibility of a genetic consultation should be used.
Use in pregnancy & lactation: In a vital indication during the 1st trimester of pregnancy, a medical consultation regarding abortion is absolutely necessary.
After the 1st trimester of pregnancy, if therapy cannot be delayed and the patient wishes to continue with her pregnancy, chemotherapy may be undertaken after informing the patient of the minor but possible risk of teratogenic effects.
Mothers must not breastfeed during treatment with Holoxan.