Hello-D/Hello-D 2000 Special Precautions

Concomitant calcium administration: Adequate dietary calcium is necessary for a clinical response to vitamin D therapy.
Hypercalcemia: Progressive hypercalcemia due to overdosage of vitamin D and its metabolites may require emergency attention. Chronic hypercalcemia can lead to generalized vascular calcification, nephrocalcinosis and other soft tissue calcification. Radiographic or slit lamp evaluation of suspect anatomical regions may be useful for early detection.
In patients with normal renal function, chronic hypercalcemia may be associated with an increase in serum creatinine. While this is usually reversible, it is important to pay careful attention to factors that may lead to hypercalcemia.
Bone lesions: Adynamic bone lesions may develop if PTH levels are suppressed to abnormal levels.
Concomitant vitamin D intake: Evaluate vitamin D ingested in fortified foods, dietary supplements, and other concomitantly administered drugs. It may be necessary to limit dietary vitamin D and its derivatives during treatment.
Hypoparathyroidism: May need calcium, parathyroid hormone, dihydrotachysterol.
Hypersensitivity reaction: Hypersensitivity to vitamin D may be one etiological factor in infants with idiopathic hypercalcemia. In these cases, severely restrict vitamin D intake.
Renal function impairment: The kidneys of uremic patients cannot adequately synthesize calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure.
Special risk: Use caution in patients, especially in the elderly with coronary disease, renal function impairment, and arteriosclerosis.
Announcement of the Food and Drug Administration: This drug can be accumulated in body's fat tissue therefore do not take excessive doses or long-term supplementation.
Take this drug only as prescribed by the physician.