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Antacids, magnesium-containing: Hypermagsenemia may develop in patients on chronic renal dialysis.
Digitalis glycoside: Hypercalcemia in patients on digitalis may precipitate cardiac arrhythmias.
Verapamil: Atrial fibrillation has occurred when supplemental calcium and calciferol have induced hypercalcemia.
Cholestyramine: Cholestyramine decreases the concentration of Vitamin D when concurrent use. Intestinal absorption of Vitamin D may be reduced.
Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol.
Mineral oil: Absorption of Vitamin D is reduced with prolonged use of mineral oil.
Phenytoin, Phenobarbital: Endogenous synthesis of calcitriol will be inhibited. Higher doses of calcitriol may be necessary if these drugs are administered simultaneously.
Thiazide diuretics: Hypoparathyroid patients on Vitamin D may develop hypercalcemia due to thiazide diuretics.
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