Feitas Mechanism of Action

Pharmacology: Pharmacodynamics: Anti-inflammatory effect: Acute inflammation: Diclofenac sodium 1% ointment demonstrated anti-inflammatory effects comparable to 1% indomethacin ointment in studies evaluating the anti-edema effect on rat paws induced by carrageenan and the anti-redness effects from ultraviolet light in guinea pigs. Additionally, this drug significantly inhibits the production of prostaglandin E2 in rat paws induced by carrageenan. A patch containing 15 milligrams per 1.5 grams of diclofenac sodium exhibited similar anti-inflammatory effects to diclofenac sodium ointment 1% in studies of the anti-oedema effect on raw paw that induced by carrageenan.
Subacute/chronic inflammation: Diclofenac sodium 1% ointment demonstrated anti-inflammatory effects comparable to 1% indomethacin ointment in studies of the anti-edema effect on rat paws induced by mustard in the paper disk assay study and in studies of anti-arthritis effects in rats stimulated by adjuvant substances. Additionally, a patch containing 15 milligrams per 1.5 grams of diclofenac sodium exhibited similar anti-inflammatory effects to diclofenac sodium 1% ointment in studies of the anti-oedema effect on raw paws induced by mustard and in anti-arthritis studies in rats induced by adjuvant substances.
Analgesic effect: Diclofenac sodium 1% ointment demonstrated pain suppression effects similar to 1% indomethacin ointment in a pain model using the acetic acid writhing test in mice and the yeast pain test in rats. Additionally, a patch containing 15 mg per 1.5 g of diclofenac sodium showed analgesic effects equivalent to 1% diclofenac sodium ointment in a pain model induced by Brewer's yeast-induced pain in rats.
Pharmacokinetics: When applying a patch containing 15 mg per 1.5 g of diclofenac sodium or diclofenac sodium 1% ointment to the back of healthy male volunteers, the concentration of diclofenac in corneum was found to be even.
Toxicology: Safety data from preclinical studies: In the initial skin irritation study, the incidence rate of erythema-type rash was minimal when applying 1% diclofenac sodium patch to intact skin or abraded skin, compared to the placebo patch.
Mild skin irritation observed in the volunteers was found to be caused by non active ingredients contained in the patch.
In a 14-day continuous skin irritation study, the 1% diclofenac sodium patch did not cause cumulative skin irritation.