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Pregnancy Category: C.
Safe use of ethionamide during pregnancy has not been established. The drug has caused teratogenic effects in rabbits and rats when administered in high doses. There are no adequate and controlled studies to date using ethionamide in pregnant women, and it is stated that the drug should not be used in women who are or may become pregnant unless the clinician considers the drug essential to treatment.
The effect to ethionamide on labor and delivery in pregnant women is unknown. Because it is not known whether ethionamide is distributed into human milk, the drug should be administered to nursing mothers only if the benefits of therapy outweighs the potential risks to the infant. It is stated that if ethionamide is administered during breastfeeding, the infant should be monitored for adverse effects.
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