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Alcohol: Patients receiving ethionamide should avoid excessive ingestion of alcohol because a psychotic reaction has been reported in this situation.
Antituberculosis agents: Serum concentrations of isoniazid may increase temporarily during concomitant ethionamide therapy. Ethionamide may potentiate the adverse effects of other antituberculosis agents included in the treatment regimen. There is some evidence that adverse nervous system effects of ethionamide, cycloserine, and isoniazid may be additive. Seizures have been reported in patients receiving regimen that included both ethionamide and cycloserine and caution is advised if these drugs are used concomitantly.
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