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The symptoms of overdosage with Diutropan (oxybutynin chloride) may be any of those seen with other anticholinergic agents. Symptoms may include signs of central nervous system, excitation (eg, restlessness, tremor, irritability, convulsion, delirium, hallucination), flushing, fever, nausea, vomiting, tachycardia, hypotension or hypertension, respiratory failure, paralysis and coma.
In the event of an overdose or exaggerated response, treatment should be symptomatic and supportive. Maintain respiration and induce emesis or perform gastric lavage (emesis is contraindicated in precomatose, convulsive or psychotic state). Activated charcoal may be administered as well as cathartic. Physostigmine may be considered to reverse symptoms of anticholinergic intoxication. Hyperpyrexia may be treated symptomatically with ice bags or other cold applications and alcohol sponge.
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