Diutropan Mechanism of Action

Therapeutic category: Antispasmodic, anticholinergic.
Diutropan exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Diutropan exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blocking effects occur at skeletal neuromuscular junction or autonomic ganglia (antinicotinic effects).
Diutropan relaxes bladder smooth muscle. In patients with condition characterized by involuntary bladder contractions, cystometric studies have demonstrated that Diutropan increases bladder (vesical) capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle and delays the initial desire to void. Diutropan thus decreases urgency and the frequency of both incontinent episodes and voluntary urination.
Diutropan was well tolerated in patients administered with the drug in controlled studies of 30 days' duration and in uncontrolled studies in which some of the patients received the drug for 2 years.