Sign Out
Effects on the Laboratory Results: Administration of indocyanine green has been reported to cause and increase in serum inorganic iodide concentrations and decrease in radioactive iodide uptake in several patients due to sodium iodide in the product. Therefore, examinations using indocyanine green should be conducted with at least 1 week interval before the thyroid radioactive iodide uptake test, which may be influenced by the use of the drug. Heparin preparations containing sodium bisulfate should not be used as the anticoagulant for the collection of samples for analysis as these solutions reduce the peak absorption of indocyanine green in blood.
Precaution Concerning Diagnosis: There may be some errors in estimated values of liver function test in following cases: Effect of the Following Physical Condition: Chylous serum or extremely turbid or hemolytic serum; edema, emaciation, obesity or massive blood loss. (In this case, the plasma elimination rate method should be used for measurement)
Effect of Concomitant Therapy: Biliary contrast agents (eg, iotroxate meglumine), choleretic agents, rifampicin and antigout agents. (Concomitant use of these drugs with Diagnogreen may inhibit uptake of indocyanine green into hepatocytes).
Phenobarbital: It can decrease the t½ of indocyanine green, presumably because of an increase in hepatic dye transport induced by phenobarbital. Simultaneous administration of indocyanine green and sulfobromophthalein sodium (BSP) may result in an impairment of hepatic excretion of BSP, particularly in patients with hepatic impairment. The presence of BSP in blood may cause changes in the maximum absorption spectrum of indocyanine green, and simultaneous use of these agents should be avoided.
Effect of Substances Other Than Drug: Effect of Food: Hepatic blood flow may be increased. Intake of dietary fat may increase the blood lipid level and the serum may become clouded.
Incompatibilities: Indocyanine green should not be dissolved by normal saline solution (NSS).
Continue with Google