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Causes sedation, caution must be used in performing tasks which require alertness (ie, operating machinery or driving).
Sedative effects of CNS depressants or ethanol are potentiated. Use with caution in patients with angle-closure glaucoma, pyloroduodenal obstruction (including stenotic peptic ulcer), urinary tract obstruction (including bladder-neck obstruction and symptomatic prostatic hypertrophy), hyperthyroidism, increased intraocular pressure, and cardiovascular disease (including hypertension and tachycardia). Diphenhydramine has high sedative and anticholinergic properties, so it may not be considered the antihistamine of choice for prolonged use in elderly.
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