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Patients with history of hypersensitivity to Clozapine or any other components of the formulation.
Patients with history of toxic or idiosyncratic granulocytopenia or agranulocytosis (with the exception of granulocytopenia/agranulocytosis from previous chemotherapy).
Patients with myeloproliferative disorders.
Patients with history uncontrolled epilepsy.
Patients with alcohol psychosis or other toxic psychosis, drug intoxication, comatose conditions.
Patients with blood circulation collapse.
Patients with CNS depression of any cause.
Patients with hepatic failure, renal failure or cardiac failure.
Do not use in combination with other agents having a bone marrow suppression activity or long acting antipsychotics which may be potentially myelosuppressive from the body rapidly in situations where this may be required, e.g granulocytopenia.
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