Treatment with CLORIL is indicated in treatment-resistant schizophrenic patients only, i.e. schizophrenic patients who are non-responsive to or intolerant of classic neuroleptics. Non-responsiveness is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two marketed neuroleptics prescribed for adequate durations. Intolerance is defined as the impossibility of achieving adequate clinical benefit with classic neuroleptic drugs because of severe and untreatable neurological adverse reactions (extrapyramidal side effects of tardive dyskinesia.)