Cefazillin Drug Interactions

Metabolism: None known.
Vaccine, live: Cephalosporins may decrease the effectiveness of live vaccine. Concurrent use is not recommended.
Ethanol: Alcoholic beverages consumed concurrently with or 72 hours or less after cefazolin may produce acute alcohol intolerance (disulfiram-like reaction). This antibiotic posses a methyltetrazolethiol side chain that may inhibit aldehyde dehydrogenase. The reaction begins within 30 minutes after alcohol ingestion and may subside 30 minutes to several hours afterward; the reaction may occur 3 days or less after the last dose of the antibiotic.
Sodium picosulfate: Antibiotics may diminish the therapeutic effect of sodium picosulfate. Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic.
Vitamin K antagonists: Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists. Monitor therapy.
Loop diuretics: Use cephalosporins with caution in patients receiving potent diuretics (eg. Loop diuretics). The risk of nephrotoxicity may be increased. Monitor renal function.
Probenecid: Probenecid may increase and prolong cephalosporin plasma levels by competitive inhibiting renal tubular secretion. This is the most significant for cephalosporins primarily by tubular secretion.