Cefazillin Dosage/Direction for Use

Recommended Dose: Adult and Geriatric: Usual dosage: For a list of infections, refer to Indications/Uses.
Mild infections caused by susceptible gram-positive cocci: 250-500 mg IM or IV every 8 hours.
Moderate to severe infections: 500 mg to 1 g IM or IV every 6-8 hours.
Severe, life-threatening infections (eg, endocarditis, septicemia): 1-1.5 g IM or IV 6 hours. In rare instances, up to 12 g daily has been used.
Group B streptococcus (perinatal prophylaxis): 2 g IV at the time of onset of labor or rupture of membranes followed by 1 g IV every 8 hours until delivery.
Perioperative prophylaxis: 1-2 g IM or IV administered 30 minutes to 1 hour prior to the start of surgery. For procedures 2 hours or more, 500 mg to 1 g IM or IV during surgery. 500 mg to 1 g IM or IV every 6-8 hours for 24 hours postoperatively. In surgery where the occurrence of infection may be particularly devastating (eg, open-heart, prosthetic arthroplasty), the prophylactic administration of cefazolin injection may be continued for 3 to 5 days following the completion of surgery.
Pneumococcal pneumonia: 500 mg IM or IV every 12 hours.
Urinary tract infections (uncomplicated): 1 g IM or IV every 12 hours.
Pediatric: Usual dosage: For a list of infections, refer to Indications/Uses. Children >1 month: 25-50 mg/kg daily IM or IV divided in 3 or 4 doses. May increase to 100 mg/kg daily divided to 3 or 4 doses for severe infections. Maximum 6 g daily.
Renal Impairment: Adult: Creatinine clearance 35-54 mL/minute: Administer full dose in intervals of 8 hours or more.
Creatinine clearance 11-34 mL/minute: Administer 50% of usual dose every 12 hours.
Creatinine clearance ≤10 mL/minute: Administer 50% of usual dose every 18 to 24 hours.
Pediatric: Creatinine clearance >70 mL/minute: No dosage adjustment necessary.
Creatinine clearance 40-70 mL/minute: 60% of usual daily dose divided every 12 hours.
Creatinine clearance 20-40 mL/minute: 25% of usual daily dose divided every 12 hours.
Creatinine clearance 5-20 mL/minute: 10% of usual daily dose divided every 24 hours.
Mode of Administration: Cefazillin is a sterile powder for injection. Reconstituted solutions of cefazolin are light yellow to yellow. Before administer, visual examination should be performed to ensure that there are no visible particles and the color does not change.
Preparation: CEFAZILLIN vials should be reconstituted with sterile water for injection as shown in the table as follows. (See table.)

Click on icon to see table/diagram/image

Administration: IM: Inject deep IM into large muscle mass.
IV: Inject direct IV over 3 to 5 minutes or may infuse as an intermittent infusion over 30 to 60 minutes.
Admixture compatibility: Stable in D5W, D5LR, D5¼NS, D5½NS, D5NS, D10W, LR, NS.
Compatible: Acyclovir, allopurinol, alprostadil, amifostine, anidulafungin, atracurium, aztreonam, bivalirudin, calcium gluconate, cyclophosphamide, cyclosporine, dexmedetomidine, diltiazem, docetaxel, doxorubicin liposome, enalaprilat, esmolol, etoposide phosphate, famotidine, fenoldopam, fentanyl, filgrastim, fluconazole, fludarabine, foscarnet, gallium nitrate, gemcitabine, granisetron, heparin, hetastarch in lactate electrolyte injection (Hextend), insulin (regular), labetalol, lidocaine, linezolid, magnesium sulfate, melphalan, meperidine, midazolam, milrinone, morphine, multivitamins, nicardipine, ondansetron, oxytocin, palonosetron, pancuronium, propofol, ranitidine, remifentanil, sargramostim, tacrolimus, teniposide, theophylline, thiotepa, vecuronium, vitamin B complex with C, warfarin.
Incompatible: Amphotericin B cholesteryl sulfate complex, caspofungin, idarubicin, pemetrexed, pentamidine, vinorelbine.